UK could get 10million doses of Pfizer's Covid vaccine BEFORE Christmas as breakthrough reveals drug giant's jab 'prevents 90% of people from catching disease' and markets soar to highest levels since August
- 'Really impressive' progress means company will soon seek approval in the US
- UK has ordered 30million doses of the jab - enough to cover 15m people
- Look at final trial results so far suggest no more than eight people got Covid-19
- Of 94 people infected in the study, over 90% did not receive the real vaccine
- Pfizer chairman today hailed the progress 'a great day for science'
One of the leading coronavirus vaccine candidates has proven to be 90 per cent effective, marking a major breakthrough in the global race to stop the disease.
The UK's stock market surged this morning when Pfizer and BioNTech said that early results from a massive clinical trial suggest nine out of 10 people who get their jab are protected from coronavirus by it.
In an update on progress in the ongoing study, the pharmaceutical companies said that of 94 people infected with the virus so far, at least 86 of them had been in the placebo group
The company's chairman hailed the breakthrough a 'great day for science' while independent experts said the results are 'excellent' and 'really impressive'.
Pfizer and BioNTech are expected to apply for approval to give out the jab in the US as soon as possible, but they must wait for long-term safety data to be completed.
Shortly after the news broke, Downing Street announced Boris Johnson would hold a TV briefing at 5pm this afternoon.
The vaccine is one of at least seven that have already been pre-ordered by the UK Government, which has secured a deal for 30million doses of it. The jab has to be given in two instalments so the UK's current order could cater to 15million people.
Stocks surged on the news, with Britain's FTSE 100 index rising 247 points - five per cent - at around midday, with more than £83billion added to its total value today. And Pfizer's listing on the French exchange increased by 14 per cent, while its shares in New York were up more than 12 per cent in pre-market trading.

A vaccine trial volunteer in Turkey receives a dose of the Pfizer and BioNTech jab at the end of October. The study is ongoing and has already enrolled more than 43,000 people around the world

Pfizer and BioNTech have produced one of the world's leading candidates for a coronavirus vaccine, and have become the first to report early results from their final study
Pfizer and German partner BioNTech are the first drugmakers to show successful data from a large-scale clinical trial of a coronavirus vaccine.
They said that 94 people in a trial of more than 43,000 have so far tested positive for Covid-19, and that over 90 per cent of those did not receive the real vaccine.
The companies have not revealed the exact number but a 90 per cent efficacy rate suggests that no more than eight people who got the vaccine caught the virus, compared to 86 of those who received a fake jab.
If it is approved in the US, the UK could follow suit soon after. Kate Bingham, chief of the UK's coronavirus vaccine taskforce, said earlier this month that 10million doses of Pfizer's jab could be available in Britain by January.
Scientists said today's news was a breakthrough in the global race to develop a jab to try and stop the pandemic.
Dr Paul Hunter, a medicine and infectious disease expert at the University of East Anglia, told MailOnline: 'If it holds up in the final analysis, that's a remarkably good result.
'There's always a big question of how long it will last, of course. You might need re-boosting every year, we don't know. It could all go pear-shaped still.
'Providing we get this vaccine and it is delivered as planned then it'll make a very big difference within a matter of months.'
On whether the jab could still fail despite promising early results, he added: 'It's always a possibility. Most of the time the final results are in line with the interim results but you can't guarantee it.
'I'm really pleased about this result you can almost begin to start seeing the light at the end of the tunnel. I just hope it's not an oncoming train.'
Scientists across the UK have said the results are cause for optimism but are still only early indications, so it is important to not get carried away.
The University of Oxford's Professor Peter Horby, who led the team that proved the steroid dexamethasone could save dying coronavirus patients, said: 'This news made me smile from ear to ear.
'It is a relief to see such positive results on this vaccine and bodes well for Covid-19 vaccines in general. Of course we need to see more detail and await the final results, and there is a long long way to go before vaccines will start to make a real difference, but this feels to me like a watershed moment.'
Professor Brendan Wren, from the London School of Hygiene & Tropical Medicine, said: 'A 90 per cent efficacy for a phase 3 trial is excellent for a new vaccine that could make a huge difference, but more confirmatory safety and efficacy studies are required.
'The RNA-based vaccine requires two doses and its true efficacy over a longer period of time remains to be evaluated. These are encouraging results and it is a case of so far so good.'
Professor Eleanor Riley, an immunology and infectious disease expert at the University of Edinburgh, added: 'At face value, this is exceptionally good news: a vaccine that is 90 per cent effective at preventing symptomatic cases of Covid-19 and with millions of doses available by the end of the year.
'However, the full data set on which the claim is based has not yet been released and so we don’t know exactly what has been found.
'The two companies are at pains to point out that the trial participants are ethnically diverse, which is good, but say nothing about the age of people in the trial. If a vaccine is to reduce severe disease and death, and thus enable the population at large to return to their normal day-to-day lives, it will need to be effective in older and elderly members of our society.
'We also know nothing yet about the severity of cases that were seen in the trial, whether infection or infectiousness was prevented, or how long the immunity is expected to last.
'But I think we have reason to be cautiously optimistic.'
Optimism was the reaction of the stock markets when the news broke, with the UK's FTSE surging to its highest level since August and some companies seeing boosts of more than a third.
In the US, already on a high after the election delivered a clear result, Dow futures jumped 4.2 per cent, and the S&P 500 rose 3.1 per cent.
Pfizer shares, listed in New York, were up more than 10 per cent in pre-market trading.
The FTSE 100 index was up more than 4.5 per cent on the news, which put it at the highest level since mid-August, while other markets around the world also recorded sharp gains.
Airline group IAG was up 35 per cent, while Rolls Royce saw a 30 per cent spike.
Cinema and hotel chains also received a massive boost as investors digested the optimistic signs.
In Europe, France's CAC 40 jumped 5.6 per cent to 5,239, while Germany's DAX surged 5.1 per cent to 13,112.
Pfizer and BioNTech said they have so far found no serious safety concerns and expect to seek US emergency use authorization later this month.
If authorized, the number of vaccine doses will initially be limited. Many questions also remain including how long the vaccine will provide protection.
However, the news provides hope that other vaccines in development against the novel coronavirus may also prove effective.
'Today is a great day for science and humanity,' said Albert Bourla, Pfizer's chairman and chief executive.
'We are reaching this critical milestone in our vaccine development program at a time when the world needs it most with infection rates setting new records, hospitals nearing over-capacity and economies struggling to reopen.'
Pfizer expects to seek broad US emergency use authorization of the vaccine for people aged 16 to 85.
To do so, it will need to have collected two months of safety data on around half of the study's roughly 44,000 participants, which is expected to be completed in late November.
'I'm near ecstatic,' said Dr Bill Gruber, one of Pfizer's top vaccine scientists. 'This is a great day for public health and for the potential to get us all out of the circumstances we're now in.'
The efficacy rate is well above the 50 per cent effectiveness required by the US Food and Drug Administration for a coronavirus vaccine.
To confirm its efficacy rate, Pfizer said it will continue the trial until there are 164 Covid-19 cases among participants. Given the recent spike in US infection rates, that number could be reached by early December, Dr Gruber said.

Pictured is the first patient to have received the Pfizer vaccine, at the University of Maryland in May this year. Since then, more than 43,000 people have been enrolled in the ground-breaking trial
The data have yet to be peer-reviewed or published in a medical journal. Pfizer said it would do so once it has results from the entire trial.
Pfizer and BioNTech have a $1.95billion (£1.45m) contract with the US government to deliver 100 million vaccine doses beginning this year. They have also reached supply agreements with the European Union, the UK, Canada and Japan.
To save time, the companies began manufacturing the vaccine before they knew whether it would be effective, and they now expect to produce up to 50million doses, or enough vaccine to protect 25million people, this year.
Pfizer said it expects to produce up to 1.3billion doses of the vaccine in 2021.
The vaccine uses messenger RNA (mRNA) technology, which relies on synthetic genes that can be generated and manufactured in weeks, and produced at scale more rapidly than conventional vaccines.
Moderna Inc, whose vaccine candidate employs similar technology, is expected to report results from its large-scale trial later this month. The mRNA technology is designed to trigger an immune response without using pathogens, such as actual virus particles.
Pfizer alone will not have the capacity to immediately provide enough vaccines for the entire United States. The Trump administration has said it will have enough supply for all of the 330million U.S. residents who wish to be vaccinated by the middle of 2021.
No comments: